Abstract
In this report, we present the application of Pudovik reaction in the synthesis of chiral organophosphorus compounds and shown this reaction to be a promising way to enantiopure aminophosphonic acid derivatives. Cyclization reactions are a new, most efficient strategy for stereoselective synthesis of α-aminophosphonates, namely an intramolecular type of interaction of the P(III) atom and an imino group.
Acknowledgments
This article was presented at the 17th International Conference on Phosphorus Chemistry (ICPC-17), April 15–21, 2007, Xiamen, China.
This work was supported by the Civilian Research and Development Foundation (grant no. RUC2-2638-KA-05) and the Russian Foundation for Basic Research (grant no. 07-03-00617).