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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 184, 2009 - Issue 7
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Original Articles

Oxidation of Thiols Using K2S2O8 in Ionic Liquid

Abdol R. Hajipour Department of Pharmacology, University of Wisconsin, Medical School, Madison, Wisconsin, USA; Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, Iran
,
Majid Mostafavi Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, Iran
&
Arnold E. Ruoho Department of Pharmacology, University of Wisconsin, Medical School, Madison, Wisconsin, USA
Pages 1920-1923 | Received 28 Apr 2008, Accepted 14 Aug 2008, Published online: 22 Jun 2009
 
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Abstract

A green, straightforward, and novel method for oxidation of thiols to the corresponding disulfides is reported using K 2 S 2 O8 in the ionic liquid 1-butyl-3-methylimidazolium bromide [(bmim)Br] at 65–70°C. The corresponding disulfides were obtained in excellent yield and short reaction time.

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), I.R. Iran (A. R. H.), and Grants GM 033138, MH 065503, and NS 033650 (A. E. R.) from the National Institutes of Health, USA. Further financial support from Center of Excellence in Sensor Chemistry Research (IUT) is gratefully acknowledged.

Notes

a Confirmed by comparison with authentic samples (IR, TLC, and NMR).

b Oxidant/thiol/ionic liquid (1.0:1.0:1.0).

c Yield of isolated pure product after chromatography or distillation.

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