A Convenient Method for the Aerobic Oxidation of Thiols to Disulfides

Abstract

Thiols are oxidized to the corresponding disulfides using K⁺/CH ₃ CN system under ambient conditions in the presence of air. This system provides a convenient, rapid, and efficient aerobic oxidative for the syntheses of symmetrical disulfides.

Keywords:

• Aerobic oxidative
• disulfide
• K⁺/CH₃CN
• thiol

We gratefully thank the China 973 Program (grant No. 2003CB114406) and the National Natural Science Foundation of China (grant No. 20772069) for financial support of this research.

Notes

^a The reaction was completed in the mentioned time.

^b The reaction was not completed in the mentioned time.

^a Isolated yield by silica-gel column chromatography.

^b Isolated yield by direct filtration, evaporation.

^c Purity assessed by HPLC.

^d Yield by GC.

^e Purity assessed by GC.

^a Isolated yield by direct filtration after adding water.

^b Purity assessed by GC.

^a Isolated yield by silica-gel column chromatography.

^b Yield by GC.