Synthesis and Biological Activity of O,O-Dimethyl-2,6-Pyridinyl Diformyloxy Alkyl Phosphonates

Abstract

In an attempt to discover novel compounds with high activity and low toxicity, a series of new O,O-dimethyl-2,6-pyridinyl diformyloxy alkyl phosphonates 4a–4p has been designed and synthesized by the reaction of 2,6-pyridinyl diformyloxy chloride with α-hydroxyalkyl phosphonate. The structures of all new compounds were characterized by elementary analysis, IR, ¹H NMR, and MS spectroscopies. The results of a preliminary bioassay indicate that some of the target compounds have obviously promotive action for plant growth against the stalk of barnyard grass.

Keywords:

• Biological activities
• O,O-dimethyl-2,6-pyridinyl diformyloxy alkyl phosphonates
• synthesis

We are grateful to the National Natural Science Foundation of China (No. 20862007) and Natural Science Foundation of Jiangxi Province (No. 2007GZH1399).