An Efficient Synthesis and Antibacterial Screening of Novel Oxazepine α-Aminophosphonates by Ultrasound Approach

Abstract

An efficient synthesis of novel α-aminophosphonates by the reaction of quino[2,3-b][1,5]benzoxazepines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst p-toluene sulphonic acid (p-TSA). This method affords the α-aminophosphonates under the influence of ultrasound irradiation in solvent-free conditions, in short reaction times (4–6 min), high yields (80–90%), with improved purity. The synthesized α-aminophosphonates show antibacterial activity against Gram-positive and Gram-negative bacteria.

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Keywords:

• α-Aminophosphonates
• p-TSA
• quino[2,3-b][1,5]benzoxazepine
• solvent-free
• triethyl phosphite
• ultrasound irradiation

Acknowledgments

The authors are thankful to the Head, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India for providing laboratory facilities.