Anti-Alzheimer and Anti-Cox-2 Activities of the Newly Synthesized 2,3′-Bipyridine Derivatives (I)

Abstract

3-Aryl-1-pyridin-3-ylprop-2-en-1-ones 1a,b reacted with 2-cyanoethane-thioamide (2) to afford the corresponding 4-aryl-6-thioxo-1,6-dihydro-2,3′-bipyridine-5-carbonitriles 6a,b. The synthetic potentiality of compounds 6a,b were investigated in the present study via their reactions with several active-hydrogen containing compounds 8a–g aiming to synthesize 4-aryl-6-pyridin-3-ylthieno[2,3-b]pyridin-3-amines 10a–n via 6-(alkylthio)-4-aryl-2,3′-bipyridine-5-carbonitriles 9a–n. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, ¹H NMR, and mass spectra, as well as that of elemental analyses. Anti-Alzheimer and anti-COX-2 activities for all newly synthesized heterocyclic compounds were investigated.

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Keywords:

• 6-(Alkylthio)-4-aryl-2, 3′-bipyridine-5-carbonitriles
• 3-aryl-1-pyridin-3-ylprop-2-en-1-ones
• 2-cyanoethanethioamide
• 6-pyridin-3-ylthieno-[2,3-b]pyridin-3-amines
• 6-thioxo-1, 6-dihydro-2,3′-bipyridine-5-carbonitrile