Melamine Hydrogen Peroxide (MHP): Novel and Efficient Reagent for the Chemo- and Homoselective and Transition Metal–Free Oxidation of Thiols and Sulfides

Abstract

Melamine hydrogen peroxide (MHP) as a novel hydrogen peroxide adduct was easily prepared. Both chemo- and homoselective oxidation of thiols and sulfides to their corresponding disulfides and sulfoxides occurred by using MHP in moderate to excellent yields. AlCl₃ acts as a suitable activator in the oxidation of sulfides with MHP.

Keywords:

• Disulfides
• homoselective oxidation
• melamine hydrogen peroxide
• sulfoxides
• transition metal–free oxidation

Acknowledgments

Financial support for this work by the Management and Programming Organization of I.R. Iran (special financial support of the PhD thesis of G. C.) and Center of Excellence in Development of Chemical Methods (CEDCM), Bu-Ali Sina University, Hamedan, Iran, is gratefully acknowledged.