A Convenient One-Pot Synthesis of Some New 3-(2-Phenyl-6-(2-thienyl)-4-pyridyl)hydroquinolin-2-ones Under Microwave Irradiation and Their Antimicrobial Activities

Abstract

A series of 3-(2-phenyl-6-(2-thienyl)-4-pyridyl)hydroquinolin-2-ones 4a–o were synthesized in high yields by a one–pot cyclocondensation reaction under Kröhnke's reaction conditions using 2-chloro-3-formyl quinoline 1a–c, 2-acetyl thiophene 2, and various N-phenacylpyridinium bromides 3a–e in a mixture of ammonium acetate and acetic acid by microwave irradiation. All the compounds have been characterized by elemental analysis, FT-IR, ¹H NMR, and ¹³C NMR spectral analysis. These compounds have been screened for their antimicrobial activities.

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Keywords:

• 2-Acetyl thiophene
• anti-microbial activity
• 2-chloro-3-formyl quinoline
• Kröhnke reaction condition
• microwave irradiation
• various N-phenacylpyridinium bromides

Acknowledgments

The authors are thankful to the Department of Chemistry, S.P. University, for providing research facilities and Vaibhav laboratory, Ahmedabad, for providing IR facilities.