Synthesis of Selenium Derivatives of 3-Hydroxy-2-substituted-2,3-dihydroisoindol-1-ones

Abstract

Regiospecific transformation of 3-hydroxy-2-substituted-2,3-dihydroisoindol-1-ones into their aryl and alkyl 7-selenium derivatives, via metallation and subsequent reaction with diselenides, is described.

Keywords:

• Diselenides
• isoindolinones
• ortho-lithiation
• selenides

Acknowledgments

Dedicated to Professor Marian Mikołajczyk, CBMiM PAN in Łódź, Poland, on the occasion of his 70th birthday.

The authors are grateful to the Rector of the University of Łódź for financial support (Grant No. 505/684).