Abstract
A new rapid, efficient, solvent-free, microwave-assisted, and high-yielding method for the synthesis of N,N-dialkyl-P-alkylphosphonamidic anhydrides has been developed. The method involves the use of 4-dimethylaminopyridine and water under microwave irradiation. The reaction of N,N-dialkylaminoalkyl/phenyl phosphonochloridates 2a–h with 4-dimethylaminopyridine (DMAP) gave pyridinium salts, which were converted into N,N-dialkyl-P-alkylphosphonamidic anhydrides 4a–h.
Acknowledgments
The authors thank to Ms. Mamta Sharma and Avik Mazumder for NMR analysis.
Notes
a Product yields.
b 31P NMR spectra were recorded in CDCl3 at 162 MHz.