Basic Alumina-Catalyzed, Solvent-Free Synthesis of Diversified Thioethers

Abstract

Environmentally and economically benign solvent free syntheses of thioethers are performed by the reaction of benzothiazole thiol with different halides on basic alumina—a simple, cheap, robust catalyst that couples a range of substrates with thiol in excellent yields in a short time. The in vitro antibacterial screening of compounds 3c, e, g, i, j, and k were evaluated against the Gram-positive organism Staphylococcus aureus and Gram-negative organisms. Escherichia coli and Proteus mirabilis by the Agar well diffusion method.

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Keywords:

• Basic alumina
• catalyst
• electron-deficient
• electron-rich
• thioethers

Acknowledgments

We thank Syngene International Ltd., Bangalore, India, for its generous support in spectral analysis. F. N. Khan thanks the DST, India, for Fast Track Young Scientist fellowship.

Notes

^a Benzothiazole thiol 1 (1 equiv) and 1-(chloromethyl)-4-chlorobenzene- 2a (1.2 equiv).