Synthesis of 14-Substituted-14H-Dibenzo[a,j] Xanthenes and 1,8-Dioxo-Octahydroxanthenes Using Silica Chloride (SiO₂-Cl) Under Solvent-Free Conditions

Abstract

A simple and efficient synthesis of 14-substituted-14H-dibenzo[a,j]xanthenes and 1,8-dioxo-octahydroxanthenes has been accomplished by the one-pot condensation of β-naphthol or dimedone and aldehydes under solvent-free conditions in the presence of SiO₂-Cl as a heterogeneous catalyst.

Keywords:

• Dimedone
• 1,8-dioxo-octahydroxanthenes
• β-naphthol
• silica chloride
• solvent-free
• 14-substituted-14H-dibenzo[a,j]xanthenes

Acknowledgments

We are pleased to acknowledge the financial support from Xinxiang Medical University (No. 04GXLP05).

Notes

^aAll of the isolated products are known compounds, and their spectral and physical data have been reported in the literature. ^{12 , 21 , 22a}