N,N ′-Diiodo-N,N′-1,2-ethanediylbis(p-toluenesulfonamide) as an Efficient Catalyst for Acetylation of Alcohols, Phenols, Amines, and Thiols Under Solvent-Free Conditions

Abstract

N,N′-Diiodo-N,N′-1,2-ethanediylbis(p-toluenesulfonamide) (NIBTS) is a highly efficient catalyst for the acetylation of alcohols, phenols, amines, and thiols under solvent-free conditions. Primary, secondary, tertiary alcohols; phenols; amines; and thiols can be easily acetylated in good to excellent yields at 80 °C.

Keywords:

• Acetic anhydride
• acetylation
• alcohols
• amines
• NIBTS
• phenols
• thiols

Acknowledgments

We are thankful to Bu-Ali Sina University, Center of Excellence and Development of Chemical Methods (CEDCM), for financial support.

Notes

^a Isolated yield.