Synthesis, Characterizations, and Crystal Structures of α-Hydroxyphosphonic Acid Esters

Abstract

This article describes the synthesis of α-hydroxyphosphonic acid esters using the Pudovik reaction. IR, ¹H NMR, ¹³C NMR, ³¹P NMR, MS, and elemental analysis were employed to confirm their structures. X-ray structure analysis is reported for six compounds. The antibacterial activities of these compounds are also reported.

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Keywords:

• Crystal structure
• phosphonate
• synthesis

Acknowledgments

The authors would like to acknowledge the Scientific Research Foundation of Third Institute of Oceanography, SOA (Grant no. 2009005), National Natural Science Foundation of China (Grant no. 40806032 and 20732004), and the Natural Science Foundation of Fujian Province of China (Grant no. 2009J05099).