Synthesis of Diversified Thioethers, 1-Aroylalkylisoquinolin-1-yl Thioethers, by Electrophilic S-Alkylation of 3-Phenyl Isoquinoline-1(2H)-thione

Abstract

A mild and efficient method for the synthesis of thioethers has been developed. The 3-phenylisoquinoline-1(2H)-thione underwent S-alkylation to afford structurally diverse sulfides in high yield.

Keywords:

• Halides
• single crystal study
• thioethers
• thiols

Acknowledgments

We thank the DST, India, for use of the CCD facility setup under the IRHPA-DST program at Indian Institute of Science, Bangalore, India. We also thank Syngene International Ltd., Bangalore, India, for their generous support in spectral analysis.