Abstract
Purine and pyrimidine nucleobases and other N-heterocycles have been silylated with HMDS in excellent yields in the presence of a catalytic amount of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA utilizes a shorter reaction time and higher yields of silylated nucleobases. SSA is reusable for several times without a decrease in reactivity or yield of silylated adducts.
Acknowledgments
We wish to thank the Shiraz University of Technology and Shiraz University Research Councils for partial support of this work.
Notes
a GC yield.
a GC yield.
a GC yield.
a Isolated yield.