Abstract
A new and convenient procedure has been developed for the Michael addition reaction of thioacetic acid (AcSH) to a variety of conjugated alkenes under solvent- and catalyst-free conditions. These reactions proceeded in 5–60 min and produced the desired products in good to high yields.
Notes
a Isolated yield.
a Conditions: AcSH (2 equiv.).
b Conditions: room temperature (except for entry 10).
c Isolated yields.
d Conditions: 50°C.
a d.r. = 50–73%.
b ee = 0–65%.
c ee = 20–70%.