Novel Green Procedure for the Synthesis of 2-Arylbenzothiazoles Under Microwave Irradiation in Peg 200 Or Peg 400

Abstract

An improved green procedure for the synthesis of 2-aryl- and 2-hetarylbenzothiazoles by condensation of equivalent amounts of 2,2′-diaminodiphenyldisulfides or 2-aminothiophenols and various aromatic aldehydes in PEG 200/400 under microwave irradiation has been developed. This method allows the synthesis of 2-arylbenzothiazoles in high yields and with high purity regardless of the state of the starting compounds (liquid or solid) or the nature of the substituents in the aromatic ring.

Keywords:

• 2-Aminothiophenols
• arylbenzothiazoles
• 2,2′-diaminodiphenyldisulfides
• green chemistry
• microwave

Acknowledgments

The authors acknowledge financial support (in part) of this work from the Spanish Ministerio de Ciencia e Innovación (project CTQ2008/04313).