Abstract
Various thioesters were obtained through an efficient phase-transfer catalysis method, by treating several thiophenols with different acyl chlorides, in a biphasic system composed of 10% aqueous NaOH and dichloromethane in the presence of tetrabutylammonium chloride. The thiolation reaction was complete in only 5 minutes, at 0°C.
Notes
a BnCl = tetrabutylammonium chloride; BnBr = tetrabutylammonium bromide.
b Not attempted.
c Reaction time = 20 min.
*BnC, 3 mmol; thiol, 3 mmol; (CH2)n(COCl)2, 1.5 mmol; 20 mL 10% NaOH aq., 20 mL CH2Cl2; 0°C, 5 min.