One-Pot, Three-Component Synthesis of α-Aminophosphonates Catalyzed by Acyclic Acidic Ionic Liquids

Abstract

Some acyclic acidic ionic liquids were prepared and used as the catalysts for the one-pot, three-component synthesis of α-aminophosphonates from aldehydes, amines, and trimethylphosphite at room temperature in water. The products could simply be separated from the system of catalyst/water, and the catalysts could be reused at least six times without noticeably decreasing the catalytic activity.

Keywords:

• α-Aminophosphonates
• aqueous media
• homogeneous catalysis
• ionic liquids

Acknowledgments

This work was financially supported by the Educational Commission of Jiangsu Provinces (2010 Qing Lan, Project), Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources & Environmental Protection (JLCBE 09023), and Professional Elite Foundation of Yancheng Normal University.

Notes

^a Isolated yield.