Chemoselective Synthesis of New Stable Phosphorus Ylides from the Reaction Between Triphenylphosphine and Activated Acetylenic Esters in the Presence of Heterocyclic Biological Bases

Abstract

A facile and chemoselective one-pot synthesis of novel stable phosphorus ylides has been developed from the reaction between triphenylphosphine and dialkyl acetylenedicarbocxylates in the presence of (heterocyclic) biological bases such as purine, theophylline, 6-azauracil, and 6-aza-2-thiothymine at ambient temperature.

GRAPHICAL ABSTRACT

Keywords:

• 6-Aza-2-thiothymine
• 6-azauracil
• purine
• stable phosphorus ylides
• theophylline

Acknowledgments

We gratefully acknowledge support of this work by the Research Council of the University of Sistan & Baluchestan.