Abstract
An efficient and facile synthesis of 2,4-disubstituted thiazoles is achieved by a one-pot reaction of aldehydes and α-bromoketones with thiosemicarbazide by grinding under catalyst- and solvent-free conditions. This method has notable advantages in terms of simple workup, neat conditions, high yield, reasonably rapid reaction rate, and environmental friendliness.
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GRAPHICAL ABSTRACT
Acknowledgements
We are grateful to the National Key Technology R&D Program (No. 2007BAI34B00) and the Natural Science Foundation of Zhejiang Province (No. Y4080107) for financial support.
Notes
aReaction conditions: thiosemicarbazide (1.0 mmol), α-bromoketone (1.0 mmol), aldehyde (1.0 mmol) by grinding at room temperature for 5 min.
bIsolated total yield.