Synthesis and Antiviral Activity of Some (3,4-Diaryl-3H-thiazol-2-ylidene)pyrimidin-2-yl Amine Derivatives

Abstract

Thirteen new (3,4-diaryl-3H-thiazol-2-ylidene)pyrimidin-2-yl amine derivatives were synthesized by reacting 1-aryl-3-pyrimidin-2-yl-thiourea derivatives and phenacyl bromides in absolute ethanol. The solid that separated was filtered and recrystallized from ethanol. The structures of the synthesized compounds were confirmed by elemental analyses and ¹H NMR, ¹³C NMR, and EI-MS spectral data.

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GRAPHICAL ABSTRACT

Keywords:

• Antiviral activity
• pyrimidine
• thiazole

Acknowledgements

The antiviral evaluations were carried out by Dr. Michel Liuzzi (Idenix Senior Director Virology, Laboratorio Cooperativo Idenix–Universita di Cagliari, Italy) and his team. Their contributions, as well as that of Dr. Gilles Gosselin (CNRS Research Director, Senior Scientist Fellow, Idenix Montpellier, France), are gratefully acknowledged.