A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture

Abstract

In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and ¹H NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.

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GRAPHICAL ABSTRACT

Keywords:

• Biological activities
• diphenyl carbonate
• synthesis
• thiazolopyridine
• urea

Acknowledgements

The authors are grateful to the National Natural Science Foundation of China (No. 20702027) and Natural Science Foundation of Tianjin (No. 07JCYBJC00100) for the financial support.