Z/E Isomerism in (Pyridinyl)aminomethane-1,1-diphosphonic Acids Derived from 2-, 3-, and 4-Aminopyridines

Abstract

The impact of specificity and topology of ring substituent(s), the protonation state of the pyridyl nitrogen atom, and the position of the aminomethane-1,1-diphosphonate portion in the pyridyl ring on the Z/E conformational preferences of 13 structurally diverse (pyridin-yl)aminomethane-1,1-diphosphonic acids is discussed based on their X-ray structures and solution studies.

Keywords:

• Bisphosphonates
• crystal structures
• Z/E isomerism

Acknowledgments

Financial support from the Polish Ministry of Science and Higher Education (project No. R05 034 03) is thankfully acknowledged.