Synthesis, Characterization, Antimicrobial, and Genotoxicity Activities of Acetoacetanilide-4-ethyl Thiosemicarbazone Complexes

Abstract

Co²⁺, Ni²⁺, Cu²⁺, Pd²⁺, Cd²⁺, UO₂²⁺, and VO²⁺ ions were found to form stable complexes with acetoacetanilide-4-ethyl thiosemicarbazone (H₂L). The structures of the complexes were elucidated by analysis (elemental and thermal), spectroscopy (electronic, IR, ESR, and ¹H NMR spectra), and physical measurements (magnetic susceptibility and molar conductance). IR spectra suggest that H₂L acts as a monodentate, bidentate, and/or tridentate ligand. The electronic spectra of the complexes and their magnetic moments provide information about the geometries. The room temperature solid state ESR spectra of the Cu(II) complexes show d_x2-y2 as the ground state, suggesting tetragonally distorted octahedral geometry around the Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in [Ni(HL)(OAc)(H₂O)] · 2 H₂O and [VO(L)(H₂O)] · 2 H₂O complexes were calculated using the Coats–Redfern equation. Finally, the antimicrobial and genotoxic activities have been tested.

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GRAPHICAL ABSTRACT

Keywords:

• Antimicrobial activity
• genotoxic activity
• ESR
• thermal analysis
• thiosemicarbazone complexes