Molecular Iodine as a Versatile Reagent for the Synthesis of Thiazoloquinoline—A Potential Antibacterial Agent

Abstract

A series of 3-(2-aminothiazol-4-yl)quinolin-2[1H]-ones 3 was prepared by neat reaction of quinolin-2[1H]-ones 1 with thioureas 2 in the presence of molecular iodine. The synthesized compounds were evaluated for their in vitro antimicrobial activities against Escherichia coli, Paedococcus sp., Lactobacillus, Yersinia enterocolitica, and Staphylococcus aureus. The green chemical approach for the synthesis of thiazoloquinolinone 3 was performed under neat conditions using molecular iodine as catalyst as well as reaction medium.

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GRAPHICAL ABSTRACT

Keywords:

• 2-Aminothiazole, 3-(2-aminothiazol-4-yl)quinolin-2(1H)-ones
• antibacterial activity
• quinoline
• thioureas

Acknowledgements

The authors wish to express their gratitude to the Indian Institute of Science, SAIF, Bangalore and Indian Institute of Technology, Chennai and Syngene International Limited for their support of NMR, HRMS facilities.