Synthesis, Antimicrobial, and Antioxidant Activity of New α-Aminophosphonates

Abstract

A new class of α-aminophosphonates 2–16 has been synthesized by the reaction of equimolar quantities of Schiff's bases with diethyl/dimethyl/diphenyl phosphite in dry toluene under reflux conditions using tetramethylguanidine (TMG) as a catalyst via Pudovik reaction in high yields (78–89%). The structures of the title compounds have been established by elemental; infrared (IR); ¹H-, ¹³C-, and ³¹P-NMR; and mass spectral data analyses. They were found to possess significant antimicrobial and antioxidant activity.

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GRAPHICAL ABSTRACT

Keywords:

• α-Aminophosphonates
• antimicrobial activity
• antioxidant activity
• 9-ethyl-3-aminocarbazole
• tertramethyl guanidine

Acknowledgments

The authors thank Dr. P. Chandra Mohan Reddy, Department of Microbiology, S. V. College of P.G. Studies, Kadapa, India, for antimicrobial studies.