Abstract
Dichlorodiorganotin (IV) R2SnCl2 (where R = Me, Bu, or Ph) on reaction with substituted hydrazones (H2L) derived from the condensation of pyridoxal hydrochloride with substituted acid hydrazides, H2pydx-inh (LI), H2pydx-th (LII), or H2pydx-nh (LIII) (pydx = pyridoxal, inh = isonicotinoyl hydrazone, th = 2-thiophene carboxyl hydrazone, nh = 1-naphthoyl hydrazone), dry benzene give pentacoordinated complexes of the type R2SnL(I-III). In the solution of isolated complexes the ligand acted in a tridentate manner (O,O,N), coordinating through a phenolic oxygen, oxygen of keto group after enolization, and nitrogen of azomethine group. The synthesized complexes were characterized by elemental analyses, molar conductance, molecular weight determination, and infrared (IR) and nuclear magnetic resonance (NMR; 1H, 13C, and 119Sn) spectral data. The ligands and their tin complexes were evaluated for antifungal and antibacterial activities, and the results indicate that they exhibit significant antimicrobial properties.
Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
GRAPHICAL ABSTRACT
Acknowledgments
The authors are grateful to the Sophisticated Analytical Instrumentation Facility (SAIF), Panjab University, Chandigarh, India, for providing NMR facilities and elemental analyses.