Microwave-Assisted Synthesis of Disulfides

Abstract

A new microwave-assisted synthesis methodology for the preparation of substituted disulfide derivatives is presented. 4-Substituted sulfenimides were reacted with 4-substituted thiols under neat (to right doughy consistency) conditions in chloroform, with both microwave heating and conventional methods. The resulting 4-substituted disulfide derivatives were obtained at higher yields and in shorter reaction times with microwave heating. Their chemistry was confirmed by ¹H-NMR, ¹³C-NMR, infrared (IR), and elemental analysis.

GRAPHICAL ABSTRACT

Keywords:

• Disulfides
• microwave
• microwave effect
• synthesis

Acknowledgments

We thank the Ondokuz Mayis University (Grant No. F-391) for financial support of this work.