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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 186, 2011 - Issue 5: 24th International Symposium on the Organic Chemistry of Sulfur
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Plenary and Invited Lectures

Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents

Jih Ru Hwu Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.; Department of Chemistry, National Central University, Jhongli City, Taiwan, R.O.C.
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Dr Shu-Yu Lin Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
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Professor Shwu-Chen Tsay Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
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Dr Raghunath Singha Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
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Dr Benoy Kumar Pal Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
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Dr Pieter Leyssen Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
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Professor Johan Neyts Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
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Pages 1144-1152 | Received 30 Jun 2010, Accepted 30 Aug 2010, Published online: 12 Jul 2011
 
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Abstract

Various conjugated compounds containing a coumarin moiety and a heterocyclic nucleus were synthesized. Their activity against hepatitis C virus was tested on subgenomic replicon replication in Huh 5-2 cells. Some heterobicycle–coumarin conjugates with the ‒S‒CH2‒ linker were found to possess appealing antiviral activities. The sulfur atom in these conjugated compounds was found to be an essential element to their antiviral activity.

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