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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 186, 2011 - Issue 4: 18th International Conference on Phosphorus Chemistry (ICPC2010)
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IV. Biologically Relevant Organophosphorus Compounds

New Lipo-Phosphoramidates for Gene Delivery

Paul-Alain Jaffrès CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Aurore Fraix CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Christophe Lorilleux CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Mathieu Berchel CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Hélène Couthon-Gourvès CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Jean-Pierre Haelters CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Jean-Jacques Yaouanc CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Laure Burel CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Philippe Giamarchi CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France
,
Patrick Midoux Centre de Biophysique Moléculaire, CNRS UPR 4301, Orléans, France
,
Tristan Montier Unité INSERM 613, Institut de Synergie des Sciences et de la Santé, Université de Bretagne Occidentale, Brest, France
&
Pierre Lehn Unité INSERM 613, Institut de Synergie des Sciences et de la Santé, Université de Bretagne Occidentale, Brest, France
 show all
Pages 918-920 | Received 01 Sep 2010, Accepted 03 Sep 2010, Published online: 25 Apr 2011
 
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Abstract

Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure–activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here.

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