Synthesis of α-Aminophosphine Oxides with Chiral Phosphorus and Carbon Atoms

Abstract

Lipophilic α-aminophosphine oxides are good extractants for liquid and membrane extraction. Optically active α-aminophosphine oxides, containing chiral centers in their structure, can provide selective means for transfer of stereoisomers through supported liquid membranes. We have developed a method for synthesis of such carrier compounds based on a three-component Kabachnik–Fields reaction.

Keywords:

• α-Aminophosphine oxide
• chiral phosphorus atom
• Kabachnik–Fields reaction
• membrane extraction
• stereoselective membrane transport