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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 186, 2011 - Issue 4: 18th International Conference on Phosphorus Chemistry (ICPC2010)
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IV. Biologically Relevant Organophosphorus Compounds

Synthesis and Characterization of Novel Fluorescent Nitrogen-Containing Bisphosphonate Imaging Probes for Bone Active Drugs

Shuting Sun Department of Chemistry, University of Southern California, Los Angeles, California, USA
,
Katarzyna M. Błażewska Department of Chemistry, University of Southern California, Los Angeles, California, USA; Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
,
Boris A. Kashemirov Department of Chemistry, University of Southern California, Los Angeles, California, USA
,
Anke J. Roelofs Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
,
Fraser P. Coxon Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
,
Michael J. Rogers Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
,
Frank H. Ebetino Warner Chilcott Pharmaceuticals, Cincinnati, Ohio, USA
,
Michael J. McKenna Harvard Medical School and Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA
&
Charles E. McKenna Department of Chemistry, University of Southern California, Los Angeles, California, USA
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Pages 970-971 | Received 15 Sep 2010, Accepted 21 Sep 2010, Published online: 25 Apr 2011
 
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Abstract

Progress in the synthesis of novel fluorescent conjugates of N-heterocyclic bisphosphonate drugs and related analogues, together with some recent applications of these compounds as imaging probes, are briefly discussed.

Acknowledgments

This work was supported by grants from the Alliance for Better Bone Health and the National Institutes of Health (1R01DC009837).

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