Knoevenagel Condensation Catalyzed by Sodium Silicate Under Solvent-Free Conditions

Abstract

Sodium silicate pentahydrate has been utilized as an efficient catalyst for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds to afford substituted olefins in yields of 80.6%∼98.9% under solvent-free conditions at room temperature within a short time. The advantages of this procedure are mild reaction conditions, excellent yields, cleaner reaction profiles, and operational simplicity.

GRAPHICAL ABSTRACT

Keywords:

• Sodium silicate pentahydrate
• aldehyde
• Knoevenagel condensation
• solvent-free

Acknowledgments

We gratefully thank Taishan University for the financial support.