3-(5-Substituted 2-Methoxyphenyl)-4-Nitro-2-Phenyl-5-Thiophene-2-yl-Isoxazolidines - Synthesis and Conformational Studies

Abstract

The synthesis of a new set of 2,3,4,5-substituted isoxazolidines having a sulfur containing heterocyclic moiety has been described. The structural features of the compounds have been analyzed by ¹H and ¹³C NMR spectroscopy as well as by single crystal X-ray studies.

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GRAPHICAL ABSTRACT

Keywords:

• 1,3-Dipolar cycloaddition
• isoxazolidine
• sulfur heterocycle
• multicomponent reaction
• microwave-assisted synthesis

Acknowledgments

The authors thank DST, New Delhi for assistance under the IRHPA program for the NMR facility. We thank SAIF for Single Crystal X-ray Diffractometer Facility at IIT Madras, India. One of the authors (SRJ) thanks Madurai Kamaraj University for a research fellowship.