OH⁻/Silica-Mediated One-Pot Synthesis of Dithiocarbamates Under Solvent-Free Conditions

Abstract

An efficient, versatile, and environmentally benign method for the synthesis of dithiocarbamates under solvent-free conditions is reported. The Michael addition of electron-deficient alkenes with alkyl or aryl amines and CS₂ in the presence of OH⁻/silica in a one-pot three-component reaction protocol gave the corresponding dithiocarbamates in good to excellent yields. This method is suitable for a wide range of amines and a variety of Michael acceptors in solvent-free conditions. The results of the present work show the desired products in excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Dithiocarbamates
• OH⁻/silica
• amines
• solvent-free
• electron-deficient alkenes

Acknowledgments

The authors thank Prof. M. R. Saidi's group (Sharif University of Technology, Iran) for their useful suggestions. This research project was supported by the Research Council of the Payame Noor University.