Clean Procedure for the Synthesis of α-Aminophosphonates Catalyzed by Biodegradable Ionic Liquid

Abstract

A biodegradable SO₃H-functionalized ionic liquid (IL) was prepared and used as the catalyst for a one-pot, three-component condensation synthesis of α-aminophosphonates from aldehydes, amines, and triethylphosphite/diethylphosphite at room temperature under solvent-free conditions or in aqueous media. The products could be simply separated from the reaction mixture and the catalyst could be recycled and reused for several times without noticeably reducing catalytic activity.

GRAPHICAL ABSTRACT

Keywords:

• α-Aminophosphonates
• ionic liquid
• biodegradable
• solvent-free
• aqueous media

Acknowledgments

This work was financially supported by the Key Laboratory of Organic Synthesis of Jiangsu Province (KJS1112), and Professional Elite Foundation of Yancheng Normal University.