Nano-TiO₂: An Eco-Friendly and Clean Reusable Heterogeneous Catalyst for Preparation of α-Aminophosphonates Under Ambient and Solvent-Free Conditions

Abstract

A one-pot catalytic three-component synthesis of α-aminophosphonates from arylaldehydes, anilines, and triethylphosphite by employing TiO₂ nanoparticles as a catalyst is described. Nano-TiO₂ has been found to be an excellent catalyst for the green synthesis of α-aminophosphonates under ambient and solvent-free conditions. This green and mild nano catalytic procedure showed good recyclability and provides cleaner conversion in a short reaction time. These advantages make the protocol feasible and economically attractive for researchers.

GRAPHICAL ABSTRACT

Keywords:

• Nano-TiO₂
• three-component reaction
• α-aminophosphonates
• catalyst
• solvent-free
• ambient conditions

Acknowledgments

We are thankful to the University of Sistan and Baluchestan Research Council for the partial support of this research.