Abstract
A method for the synthesis of novel phosphorylated aminoacetals was developed. The latter are involved in Mannich reaction as amine component with calix[4]resorcinol and formaldehyde to form tetrasubstituted macrocycles containing four acetal groups and four phosphonate (phosphine oxide) fragments on the “upper” rim of molecule with high yields.
GRAPHICAL ABSTRACT
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Acknowledgments
The work was supported by the Russian Foundation for Basic Research (grant 11-03-00416-а).