Decyl(Tri-Tert-Butyl)Phosphonium Tetrafluoroborate/Palladium Acetate: An Effective Catalyst for Cross-Coupling Reaction of Arylbromides with Phenylacetylene in Copper-Free Conditions

Abstract

The phosphonium salts with sterically hindered cation and noncoordinating anion can be used as phase-transfer reagent in the Sonogashira cross-coupling reaction allowing copper- and amine-free protocol. The reactions proceed under mild conditions with good yields.

GRAPHICAL ABSTRACT

Keywords:

• Phosphonium ionic liquid
• Sonogashira
• copper- and amine-free

Acknowledgments

The authors would like to acknowledge FASIE (r/16815) and IVF RT for financial support.