Synthesis and Antimicrobial Studies of Organophosphates Derived From 2-(2″-Hydroxynaphthyl)Benzoxazole

Abstract

A series of biologically active phenoxy derivatives of 2-substituted benzoxazole organophosphates have been synthesized by the reaction of O-(naphthyl benzoxazolyl-2-) phosphorodichloridate/phosphorodichloridothioate with phenol/4-chlorophenol/4-nitroph- enol in 1:1 and 1:2 molar ratios. These compounds have been characterized on the basis of elemental analysis, IR, ¹H NMR, ³¹P NMR, and mass spectral studies. The antibacterial activity of these 2-substituted benzoxazole phenoxy derivatives has been evaluated against pathogenic bacteria Staphylococcus aureus (+ve) and Escherichia coli (−ve). The antifungal activity of these 2-substituted benzoxazole phenoxy derivatives has been evaluated against pathogenic fungi Aspergillus niger and Fusarium oxysporium. All compounds were found to have significant antibacterial and antifungal activity.

GRAPHICAL ABSTRACT

Keywords:

• Benzoxazole
• phenoxy derivatives
• antibacterial activity
• antifungal activity

Acknowledgments

The authors ­are thankful to the Head of the Department of Chemistry, University of Rajasthan, Jaipur, India, for providing necessary facilities to carry out this research work. Priyanka Jhajharia is grateful to the University Grants Commission, New Delhi, India, for the financial support in the form of Senior Research Fellow wide grant no. 10-2(5)/2006 (i)-E.U. II.

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