One-Pot Synthesis of 1-(E)-Phenylethenyl-1,2,3-Triazoles by Sequential Click-Elimination Reaction from 2-Azido-1-Phenyl-1-(Phenylseleno)Ethane

Abstract

A new convenient one-pot, two-step procedure involving sequential click chemistry and oxidation-elimination reaction for the preparation of 1,4-disubstituted 1,2,3-triazoles bearing 1-(E)-phenylethenyl group from 2-azido-1-phenyl-1-(phenylseleno)ethane is described. The prominent features of this protocol are mild reaction conditions, operational simplicity, and good to high yields of products, as well as avoidance of the isolation of the selenated intermediate.

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GRAPHICAL ABSTRACT

Keywords:

• 1-(E)-Phenylethenyl-1,2,3-triazoles
• one-pot
• 2-azido-1-phenyl-1-(phenylseleno) ethane
• click chemistry
• oxidation-elimination

Acknowledgments

Financial support from the National Natural Science Foundation of China (No. 21062007) and the Research Program of Jiangxi Province Department of Education (Nos. GJJ10385, GJJ10733, and GJJ11380) is gratefully acknowledged.