Synthesis and Bioactivity of Some Novel 5-Arylmethylideneamino-1,3,4-Thiadiazole-2- Ylthioacetanilide Derivatives

Abstract

Some novel of 5-arylmethylideneamino-1,3,4-thiadiazole-2-ylsulfanyl acetamide derivatives were synthesized by the S-alkylation of 5-arylmethylideneamino-2-mercapto-1,3,4-thiadiazoles with chloroacetyl anilide under solid–liquid phase transfer catalysis using polyethylene glycol-400 (PEG-400) catalyst in the presence of potassium carbonate. Some of the title compounds were investigated for plant growth-regulating activity. They were found to enhance root elongation remarkably at a low concentration.

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GRAPHICAL ABSTRACT

Keywords:

• 5-arylmethylideneamino-1,3,4-thiadiazole-2-ylthioacetamides
• phase transfer catalysis
• bioactivity

Acknowledgments

This work was supported by the National Natural Science Foundation of china (NSFC) (No. 21064006 and No. 21161018), the Natural Science Foundation of Gansu Province (1010RJZA018) and the Program for Changjian Scholars and innovative Research Team in University of Ministry of Education of China (IRT1177).