Synthesis of 3-(3-(Phenacyl/Alkyl/Benzylthio)-[1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazol-6-Yl)-2H-Chromen-2-Ones

Abstract

Reaction of coumarin-3-carboxylic acid with 3,5-di mercapto-4-amino-s-triazole in POCl₃to generate 3-(3-mercapto-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)-2H-chromen-2-one (3). Reaction of 3 with different substituted phenacyl/benzyl/allyl bromides in anhydrous ethanol gave corresponding 3-(3-(phenacyl/alkyl/benzylthio)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-yl)-2H-chromen-2-ones 5. The structures of newly prepared compounds were confirmed by their analytic and spectral data.

GRAPHICAL ABSTRACT

Keywords:

• Triazole
• 1,3,4-thiadiazol
• 1,2,4-triazole
• phenacyl bromide
• coumarin

Acknowledgments

The authors are grateful to the CSIR-New Delhi for providing the financial assistance and the Director of NIT–Warangal for providing research facilities.