Abstract
Various 2-thioxo and 2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitriles were synthesized in very high yields in 40 min through a direct condensation of an equimolar amount of an aldehyde, malononitrile, and thiourea/urea under ball mill solvent-free and catalyst-free conditions.
GRAPHICAL ABSTRACT
Acknowledgments
The authors are very much thankful to King Abdulaziz City for Science and Technology (KACST) and King Saud University (KSU) for recording the analysis of synthesized compounds.