Solvent-Free Synthesis of Arylsulfonyl Cyanides Using Potassium Hexacyanoferrate(II) as An Ecofriendly Cyanide Source

Abstract

A solvent-free synthetic method for arylsulfonyl cyanides directly from corresponding sulfonyl chlorides using potassium hexacyanoferrate(II) as an ecofriendly cyanide source is described. The protocol has the advantages of no uses of highly toxic cyanating agent and volatile organic solvents, high yield, and simple work-up procedures.

GRAPHICAL ABSTRACT

Keywords:

• Arylsulfonyl cyanide
• potassium hexacyanoferrate(II)
• sulfonyl chloride
• green chemistry

Acknowledgments

The authors thank the National Natural Science Foundation of China (21162024) for the financial support of this work.