Synthesis, Crystal Structure, and Biological Activity of A Novel 1,2,3-Thiadiazole Compound Containing 1,2,4-Triazole Moiety

Abstract

A new 1,2,3-thiadiazole compound containing 1,2,4-triazole moiety, C₁₅H₁₄FN₅ O₂S₂, has been synthesized and the crystal structure was determined by single crystal X-ray diffraction study. The biological activity of the title compound was determined and the results showed that title compounds 10 showed higher inhibition abilities of rape root than the control cyclopropane-1,1-dicarboxylic acid at 100 μg/mL (73%) and weak activity against Echinochloa crusgalli (28%) and KARI (35%) at 100 μg/mL.

[Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: additional text, figures, tables.]

GRAPHICAL ABSTRACT

Keywords:

• Crystal structure
• synthesis
• 1,2,3-thiadiazole
• 1,2,4-triazole
• bioactivity