The Synthesis and Biological Activities of [5-(4-Substituted Phenylsulfinyl/Sulfonyl)-1,3-Dimethyl-1H-Pyrazol-4-Yl]-Arylmethanones

Abstract

A novel series of pyrazole derivatives containing substituted phenylsulfinyl/sulfonyl group have been synthesized via the oxidation of intermediate pyrazole sulfoether with H₂O₂ in acetic acid. The novel compounds were characterized by melting point, ¹H NMR, FT-IR, MS, and elemental analysis or HRMS. The biological activity results showed that most of the title compounds exhibit significant fungicidal activities against Alternaria solani Sorauer, Phytophthora capsici, and Corynespora cassiicola.

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GRAPHICAL ABSTRACT

Keywords:

• Pyrazole
• sulfoxide
• sulfone
• synthesis
• biological activities

Acknowledgments

This work was supported by the National Basic Research Program of China (No. 21372133), the National Key Technologies Research and Development Program (2011BAE06B05-3), and the National Natural Science Foundation of China (No. 21372133). We thank Dr. Yong-Hong Li of the Biological Assay Center, Nankai University, for herbicidal tests of compounds.