An Efficient Method for the Synthesis of Novel N-acylsulfonamides Using Tin (IV) Chloride as Catalysts

Abstract

A series of novel N-acylsulfonamides derivatives were synthesized via direct condensation of parent sulfonamide with ethyl lactate as an acylating agent in the presence of tin (IV) chloride (SnCl₄) as a Lewis acid catalyst. The sulfonamides were prepared, starting from chlorosulfonyl isocyanate (CSI), in three steps (carbamoylation, sulfamoylation, and deprotection) with excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Chlorosulfonyl isocyanate
• deprotection
• α-hydroxyester
• N-acylsulfonamide
• sulfonamide
• Tin (IV) chloride